Qing-Feng Zhang, Ying-Juan Fu, Zhan-Wang Huang, Xin-Cheng Shangguang, and Yu-Xian Guo . Nutr. Sara Albe Slabi, Christelle Mathe, Mélody Basselin, Xavier Framboisier, Mbalo Ndiaye, Olivier Galet, Romain Kapel. Yan-Jing Li, Chen-Feng Zhang, Gang Ding, Wen-Zhe Huang, Zhen-Zhong Wang, Yu-An Bi, Wei Xiao.

Bioactive Micronutrients in Coffee: Recent Analytical Approaches for Characterization and Quantification. Zhiyong He, Bo Yuan, Maomao Zeng, Jie Chen.

Separation and quantitation of isomeric caffeoylquinic acids in honeysuckle products by low-pH microemulsion electrokinetic chromatography using tartrate as a chiral selector.

The results indicated that 3-, 4- and 5-CQA tended to remain stable in acidic pH circumstance, and unstable in neutral and alkaline pH circumstance. Epub 2017 Jun 20. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780124095175000863, URL: https://www.sciencedirect.com/science/article/pii/B9780124095175000681, URL: https://www.sciencedirect.com/science/article/pii/B9780124095175000589, URL: https://www.sciencedirect.com/science/article/pii/B978012812922700010X, URL: https://www.sciencedirect.com/science/article/pii/B9780124095175000176, URL: https://www.sciencedirect.com/science/article/pii/B9780128017340000746, URL: https://www.sciencedirect.com/science/article/pii/B9780124095175000875, URL: https://www.sciencedirect.com/science/article/pii/B9780080453828001088, URL: https://www.sciencedirect.com/science/article/pii/B9780124095175000218, URL: https://www.sciencedirect.com/science/article/pii/B9780128042748000485, Chlorogenic Acid in Whole Body and Tissue-Specific Glucose Regulation, Jasmine M. Tunnicliffe, ... Jane Shearer, in, Anti-Hepatitis B Virus Activity of Chlorogenic Acid and Its Related Compounds, Role of Coffea arabica Extract and Related Compounds in Preventing Photoaging and Photodamage of the Skin, Other Compounds From Tobacco With Potential Impact on Neurodegenerative Diseases, Emilija Veljkovic, ... Manuel Peitsch, in, Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases, Pharmacological Induction of Kidney Regeneration, Elena Gagliardini, ... Norberto Perico, in, Kidney Transplantation, Bioengineering and Regeneration, Bioavailability and Metabolism of Chlorogenic Acids from Coffee. Hsiu-Mei Chiang, ... Kuo-Ching Wen, in Coffee in Health and Disease Prevention, 2015, Chlorogenic acid inhibits MMP-3 expression, but not expression of MMP-1 and MMP-9, and does not restore UVB-irradiation-induced type I procollagen damage.9 However, chlorogenic acid has been reported to inhibit the MMP-9 activity of the hepatocellular carcinoma cell line (Hep3B). Find more information about Crossref citation counts. Chlorogenic acid was isolated from green coffee beans. Chlorogenic Acid Targeting of the AKT PH Domain Activates AKT/GSK3β/FOXO1 Signaling and Improves Glucose Metabolism. in Robusta. 2017;75:114–133. It has also been implicated in weight loss and exerting an anti-obesity effect, but that is insofar correlation and not necessarily due to chlorogenic acid. CGA production also closely parallels with that of caffeine, such that, as CGA  concentrations increase so does the concentration of caffeine.

chlorogenic acid; forkhead box O1 (FOXO1); glucose metabolism; glycogen synthase kinase 3β (GSK3β); pleckstrin homology (PH) domain; protein kinase B (AKT). 2002;50:5735–5741. Sihui Liang, Hanh Lan Tran, Lilian Were. 2013;2013:801457. doi: 10.1155/2013/801457.

HHS -, Loader T.B., Taylor C.G., Zahradka P., Jones P.J.  | 

Additionally, the profile of trans-hydroxycinnamic acids was different in these fluids. Talitha Caldas dos Santos, Mariana Alves Battisti, Caroline Flach Ortmann, Flávio Henrique Reginatto, Cláudia Maria Oliveira Simões, Angela Machado de Campos. (, Multidisciplinary Digital Publishing Institute (MDPI).

Food Sci. Need to practice for the Q-Grader Acids Exam? You have to login with your ACS ID befor you can login with your Mendeley account.


Chlorogenic acids are esters of caffeic and quinic acid (Figure 3), the most common isomer being 5‐caffeoylquinic acid (Budryn and Rachwal‐Rosiak 2013). doi: 10.1021/jf0257547. A competitive combination test and hampering of AKT membrane translocation showed that CGA might bind to the pleckstrin homology (PH) domain of AKT. Effect of thermal processing and digestive protease on the antioxidant capacity of fruit juice-milk beverage model systems under simulated gastrointestinal digestion.

It forms greenish-black compounds in the presence of Fe(III) ion. 2020 Apr;8(7):480. doi: 10.21037/atm.2020.03.28. reported that chlorogenic acid suppressed apoptotic nuclear condensation induced by hydrogen peroxide in neuronal cells (12.5–100 μM for an hour). ex vivo, chlorogenic acid was shown to inhibit AChE activity in the hippocampus and frontal cortex, indicating that it may exert antiamnesic activity.494, Feifei Wei, Masaru Tanokura, in Coffee in Health and Disease Prevention, 2015, Chlorogenic acids are a family of esters formed between quinic acid and certain trans-cinnamic acids, most commonly caffeic, p-coumaric, and ferulic acid. Chlorogenic acid is the primary polyphenol in coffee, and research links it to several exciting health benefits. For instance, its hypolipidemic effect led to weight reduction in experimental mice (Ong et al., 2013). Although the term chlorogenic acid is used to identify a single compound, in reality, there are over a dozen isomers each with different sensorial characteristics. https://doi.org/10.1016/B978-0-12-409517-5.00021-8. Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice. 2017:1–13. Le Zeng, Meiling Wang, Yu Yuan, Bin Guo, Jing Zhou, Zhen Tan, Meiling Ye, Li Ding, Bo Chen. This may very well be true for coffees like robusta which contain a significant higher concentrations of di-CGA and harsher taste profile.

Environ. Elena Gagliardini, ... Norberto Perico, in Kidney Transplantation, Bioengineering and Regeneration, 2017, Chlorogenic acid (CA) is a phenolic compound widely found in fruits and vegetables (apples, pears, carrots, tomatoes, and sweet potatoes) and in coffee and tea.71 Recent evidence demonstrated the scavenging, antioxidant, and antiapoptotic activity of CA.72 In a murine model of cisplatin (CP)-induced AKI,72 the CA intraperitoneally injected 48 hours after the CP injection recovered renal function and reduced renal histologic abnormalities in terms of tubular necrosis, cast accumulation, and tubular dilatation.

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